[Tom Goldman]

If the trailer fender has enough room to allow for a larger diameter tire that will turn less revolutions per mile , yes , along with being able to go to a higher load range than is commonly available with 15" tires.
Being able to go to a load range E ,10 ply rating is a big step over the 15" tires that are commonly used on trailers.
One thing that is an absolute necessity is using bolt in type brass valve stems . Rubber stems , even the reinforced light truck type are the cause of many trailer tire blowouts .