[Bill Baer]

Well if this is to be a pump gas motor the aluminum heads are a little more detonation resistant .
The larger stroke motor will make it's power at a lower rpm than the 350 and therefore will pull better with a streetable gear and converter but I think it would be very difficult to get a street able car to run high 10's unless it's fairly light or you use nitrous.
I would research the cylinder heads carefully I believe it was hot rod that did some Dyno testing to compare SBC aluminum and cast iron heads you might want to research that article on the Internet.
If this is a race car that will not see the street, ( i.e. >4:10 gear) I would reconsider if using pump gas is the way to go.